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Natren's Megadophilus® was the first genuine probiotic, ushering in the entire category of probiotic dietary supplements and introducing the term "probiotic" to North America. Natren was the first company to introduce a single strain, concentrated Lactobacillus acidophilus powder requiring continuous refrigeration to keep the probiotic bacteria alive and stress free.

Prior to the introduction of Megadophilus in 1983, Lactobacillus acidophilus was a catch all phrase for low potency, questionable and often outright inferior products including yogurt tablets, sweet acidophilus milk, and liquid acidophilus.

Natren founder and probiotic pioneer Natasha Trenev identified, isolated and concentrated an effective single strain of acidophilus, and developed a system to keep the live bacteria's potency viable by packaging it in a glass bottle with a tin lid, and demanding refrigerated handling throughout distribution. Natren Megadophilus is also revolutionary in that the live bacteria are kept in their original culturing medium, or intrinsic supernatant. A new term post-biotic has been introduced in the dietary supplement industry. Many companies are trying to pretend they have a beneficial ingredient that they call a postbiotic. Natren is the only company that has from the very beginning included substantial additional benefits from a unique post-biotic that we call the intrinsic supernatant. The intrinsic supernatant contains special, natural , and specific antimicrobials, peptides, amino acids, and vitamins.

Natren's Megadophilus precision probiotic supplement is recommended for adults and children over two years of age. Can be administered to children younger than two along with Natren's Life Start.